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Search Results for " protein s (α) "

6

抑制剂 & 化合物

4

天然产物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T69694	(S)-DO271
	(S)-DO271 is an inactive control for the α/β-hydrolase domain-containing protein 12 (ABHD12) inhibitor DO264.
T38148	(S)-KT109 (S)-KT109
	(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 630.9 nM) than (R)-KT109 .
T74544	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine	PROTACs	PROTAC
	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 是一种能同时靶向Smad3的泛素化和降解并提高HIF-α蛋白水平的双靶点PROTAC，展现出对肾性贫血的多途径抗纤维化和肾脏保护作用。
T38031	(R)-KT109 (R)-KT109
	(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 .
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...
T36779	NG 25 (hydrochloride hydrate)
	NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv...

化合物

Cat.No: T69694

Cat.No: T38148

Synonym: (S)-KT109

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Cat.No: T74544

Target: PROTACs

Cat.No: T38031

Synonym: (R)-KT109

Cat.No: T36650

NG 25 (hydrochloride hydrate)

Cat.No: T36779

Cat. No.	Product Name	Target	Signaling Pathways
T5S1981	alpha-Cyperone (+)-α-Cyperone,α-香附酮,α-Cyperone	Others; Endogenous Metabolite	Metabolism; Others
	alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T38587	Chrysophanol triglucoside
	Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia , inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC 50 s of 80.17 and 197.06 μM, respectively. Chrysophanol triglucoside has the potential for diabetes research.
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Cat.No: T5S1981

Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone

Target: Others, Endogenous Metabolite

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

Chrysophanol triglucoside

Cat.No: T38587

Cat.No: T38330

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03848	Protein S/PROS1 Protein, Human, Recombinant (His) PS21,PSA,PS23,PS22,THPH6...	Human	HEK293 Cells
	Protein S/PROS1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.1 kDa and the accession number is P07225.
TMPY-06315	Protein S/PROS1 Protein, Cynomolgus, Recombinant (His) protein S (alpha),protein S	Cynomolgus	HEK293 Cells
	Protein S/PROS1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.18 kDa and the accession number is A0A7N9CCZ7.
TMPY-06708	Protein S/PROS1 Protein, Mouse, Recombinant (His) protein S (α),AW214361,protei...	Mouse	HEK293 Cells
	Protein S/PROS1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.75 kDa and the accession number is Q08761.
TMPY-00547	PITPN Protein, Human, Recombinant (His) phosphatidylinositol transfer	Human	HEK293 Cells
	PITPN Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is Q00169.
TMPY-00909	S100A1 Protein, Human, Recombinant (hFc) S100 calcium binding protein A1,S...	Human	HEK293 Cells
	S100A1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.1 kDa and the accession number is A0A0S2Z4H2.
TMPY-00997	S100A1 Protein, Human, Recombinant S100-α,S100A,S100 calciu...	Human	E. coli
	S100A1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 10.5 kDa and the accession number is A0A0S2Z4H2.
TMPK-01051	BLOC1S2 Protein, Human, Recombinant BLOS2,CEAP11,CEAP,BLOC-1 subunit 2	Human	E. coli
	BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. On the subcellular level, BLOC1S2 is expressed in an organellar-like pattern and co-localizes with mitochondria.
TMPH-00385	Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) P1234,Non-structural polyprotein,Polyp...	CHIKV	E. coli
	Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is Q8JUX6.
TMPH-03415	Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)	RVFV	E. coli
	Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool binds to host FBXO3 to target TFIIH subunit GTF2H1 for proteasomal degradation. Forms filaments in the nucleus that may sequester NSs binding partners, causing cell cycle arrest. Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc) is expressed...
TMPY-03603	AHSP Protein, Human, Recombinant ERAF,alpha hemoglobin stabilizing protein,...	Human	E. coli
	AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globin. It rapidly binds to ferrous α with association (k'(AHSP)) and dissociation (k(AHSP)) rate constants of ≈1 μm(-1) s(-1) and .2 s(-1), respectively, at pH 7.4 at 22 ℃. A small slow phase was observed when AHSP binds to excess ferrous αCO. This slow phase appears to be due to cis...
TMPJ-00907	GADD45A Protein, Human, Recombinant (His) GADD45,DDIT1,Growth Arrest and DNA Damage-Inducible...	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating ...
TMPJ-00554	Vinculin Protein, Human, Recombinant Metavinculin,VCL,Vinculin	Human	E. coli
	Vinculin is a focal adhesion and cytoskeletal protein that distributed mainly at cell-cell junctions and cell-extracellular matrix (ECM) adhesion that belongs to the Vinculin/α-Catenin family. Vinculin is an Actin-binding protein and component of the Actin-Linking Functional module that senses and feels the mechanical properties of the extracellular environment. Vinculin is also a key factor that couples, transmits, transduces, and regulates mechanical force between the cytoskeleton and adhesion...

重组蛋白

Protein S/PROS1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03848

Species: Human

Expression System: HEK293 Cells

Protein S/PROS1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06315

Species: Cynomolgus

Expression System: HEK293 Cells

Protein S/PROS1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06708

Species: Mouse

Expression System: HEK293 Cells

PITPN Protein, Human, Recombinant (His)

Cat.No: TMPY-00547

Species: Human

Expression System: HEK293 Cells

S100A1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00909

Species: Human

Expression System: HEK293 Cells

S100A1 Protein, Human, Recombinant

Cat.No: TMPY-00997

Species: Human

Expression System: E. coli

BLOC1S2 Protein, Human, Recombinant

Cat.No: TMPK-01051

Species: Human

Expression System: E. coli

Chikungunya virus (strain S27-African prototype) Non-structural protein 4 (His)

Cat.No: TMPH-00385

Species: CHIKV

Expression System: E. coli

Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)

Cat.No: TMPH-03415

Species: RVFV

Expression System: E. coli

AHSP Protein, Human, Recombinant

Cat.No: TMPY-03603

Species: Human

Expression System: E. coli

GADD45A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00907

Species: Human

Expression System: E. coli

Vinculin Protein, Human, Recombinant

Cat.No: TMPJ-00554

Species: Human

Expression System: E. coli

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